SYNTHESIS AND ANALGESIC ACTIVITY OF NEW 1,3,4-OXADIAZOLES AND 1,2,4-TRIAZOLES
作者： Ali Almasirad , Abbas Shafiee , Mohammad Abdollahi , Amir Noeparast , Nasir Shahrokhinejad
DOI: 10.1007/S00044-010-9335-0
关键词:
摘要: A series of new 1,3,4-oxadiazoles and 1,2,4-triazoles were synthesized in order to obtain compounds with potential analgesic activity. Compounds evaluated for their activities by formalin-induced nociception test. Mefenamic acid (as the reference drug) did not show any activity early phase formalin test, while 7b, 7c, 8c, 9a significantly reduced this phase. However late test all target mefenamic showed comparison control.
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