Histologic features associated with metastatic potential in invasive adenocarcinomas of the lung.

摘要: INTRODUCTION The International Association for the Study of Lung Cancer (IASLC) recently reclassified adenocarcinomas lung on basis histologic patterns. However, there is lack consensus about a grading system these tumors. We studied series invasive and correlated features with lymph node distant metastases. A carcinomas resected over 5-year period were retrospectively reviewed classified by IASLC system. proportion each subtype was estimated at 5% increments, cytologic blindly recorded subsequently 125 tumors predominant pattern as lepidic (LPA) (n=9), acinar (n=71), solid (n=23), papillary (n=11), mucinous (n=11). heterogeneous, in that cribriform subgroup (n=34) significantly more likely to demonstrate metastases compared tubular (n=37) had higher mitotic rate, rate necrosis, vascular invasion, prominent nucleoli. Mucinous LPA (n=3), (n=4), (n=4). metastasis greatest type (P=0.02). groups (P 20% tumor, nucleoli, along growth ≥ 20%, independently associated metastatic potential considered poor prognostic features. 3-tiered separated into well differentiated (predominantly LPA, papillary, patterns), moderately tumors), poorly (≥ pattern). Tumors well-differentiated group elevated if Using this system, stepwise increase (P<0.0001) (P=0.0004) from well-differentiated, differentiated, tumors, being 40, 46, 39, respectively. Application classification resulted predominance adenocarcinomas. To stratify clinically relevant grades, (tubular, cribriform, solid), activity, nuclear useful.