Direct optical immunosensing (sensitivity and selectivity)
作者： W. Huber , R. Barner , Ch. Fattinger , J. Hübscher , H. Koller
DOI: 10.1016/0925-4005(92)80042-V
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摘要: Abstract This paper compares theoretically predicted detection limits of three optical sensing devices (surface plasmon resonance, input grating coupler, difference interferometer) with the experimentally found for anti h-IgG antibodies. The sensitivities these sensors are confirmed satisfactorily by experiments. influence high concentrations non-analyte proteins on direct immunosensing such transducers is investigated in HBsAg (hepatitis B surface antigen) using undiluted human serum a sensitized resonance sensor; no serious was found.
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