Role of Extent of Resection in the Long-Term Outcome of Low-Grade Hemispheric Gliomas
作者： Justin S. Smith , Edward F. Chang , Kathleen R. Lamborn , Susan M. Chang , Michael D. Prados
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摘要: Purpose The prognostic role of extent resection (EOR) low-grade gliomas (LGGs) is a major controversy. We designed retrospective study to assess the influence EOR on long-term outcomes LGGs. Patients and Methods population (N = 216) included adults undergoing initial hemispheric LGG. Region-of-interest analysis was performed measure tumor volumes based fluid-attenuated inversion-recovery (FLAIR) imaging. Results Median preoperative postoperative were 36.6 cm3 (range, 0.7 246.1 cm3), 3.7 0 197.8 cm3) 88.0% 5% 100%), respectively. There no operative mortality. New deficits noted in 36 patients (17%); however, all but four had complete recovery. 34 deaths (16%; median follow-up, 4.4 years). Progression malignant progression identified 95 (44%) 44 (20%) cases, with at least 90% 5- 8-year overall survival (OS) rates 97% and...
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