DNA and protein sequence homologies between the adhesins of Mycoplasma genitalium and Mycoplasma pneumoniae.

摘要: Mycoplasma genitalium and pneumoniae are morphologically serologically related pathogens that colonize the human host. Their successful parasitism appears to be dependent on product, an adhesin protein, of a gene is carried by each these mycoplasmas. Here we describe cloning determine sequence structural for putative M. compare its counterpart P1 pneumoniae. Regions homology were consistent with observed serological cross-reactivity between adhesins detected at both DNA protein levels. However, degree two genes their products was much higher than anticipated. Interestingly, A + T content calculated as 60.1%, which substantially tham (46.5%). Comparisons codon usage organisms revealed preferentially used A- T-rich codons. total 65% positions 3 56% 1 in codons either or T, whereas utilized frequency 40 47%, respectively. The biased choice could also account preferential use conservative amino acid substitutions found adhesin. These facts suggest might have evolved independently other mycoplasma species, including