A case of distal extrahepatic cholangiocarcinoma with two positive resection margins

作者: Wayne A. Warner , Wesley Ramcharan , Dave Harnanan , Srikanth Umakanthan , Ravi Maharaj

DOI: 10.3892/OL.2016.5174

关键词:

摘要: Cholangiocarcinoma is an uncommon primary malignancy of the biliary tract that challenging to diagnose and treat effectively due its relatively silent late clinical presentation. The present study reports a case 60-year-old male with distal extrahepatic cholangiocarcinoma 3-week history painless obstructive jaundice symptoms subjective weight loss. Imaging revealed obstructing lesion in common bile duct, just entrance cystic duct. Pathology moderately differentiated two positive proximal resection margins. margins presented challenge during surgery points urgent need for further studies better illuminate diagnostic therapeutic options patients similar clinicopathological

参考文章(36)
Daniel V T Catenacci, Daniel M Geynisman, Toward personalized treatment of advanced biliary tract cancers. Discovery Medicine. ,vol. 14, pp. 41- 57 ,(2012)
Carey Lc, Bloomston M, Serafini Fm, Murr Mm, Rosemurgy As, Sachs D, Karl Rc, Location, not staging, of cholangiocarcinoma determines the role for adjuvant chemoradiation therapy. American Surgeon. ,vol. 67, pp. 839- 844 ,(2001)
Giovanni Brandi, Andrea Farioli, Annalisa Astolfi, Guido Biasco, Simona Tavolari, Genetic heterogeneity in cholangiocarcinoma: a major challenge for targeted therapies. Oncotarget. ,vol. 6, pp. 14744- 14753 ,(2015) , 10.18632/ONCOTARGET.4539
H Ohshima, D M Parkin, V Vatanasapt, P Srivatanakul, Cholangiocarcinoma: epidemiology, mechanisms of carcinogenesis and prevention. Cancer Epidemiology, Biomarkers & Prevention. ,vol. 2, pp. 537- 544 ,(1993)
Seung-Mo Hong, Timothy M. Pawlik, HyungJun Cho, Bhuvnesh Aggarwal, Michael Goggins, Ralph H. Hruban, Robert A. Anders, Depth of tumor invasion better predicts prognosis than the current American Joint Committee on Cancer T classification for distal bile duct carcinoma Surgery. ,vol. 146, pp. 250- 257 ,(2009) , 10.1016/J.SURG.2009.02.023
Attila Nakeeb, Henry A. Pitt, Taylor A. Sohn, JoAnn Coleman, Ross A. Abrams, Steven Piantadosi, Ralph H. Hruban, Keith D. Lillemoe, Charles J. Yeo, John L. Cameron, Cholangiocarcinoma. A spectrum of intrahepatic, perihilar, and distal tumors. Annals of Surgery. ,vol. 224, pp. 463- 475 ,(1996) , 10.1097/00000658-199610000-00005
Günter Klöppel, Volkan Adsay, Björn Konukiewitz, Jörg Kleeff, Anna Melissa Schlitter, Irene Esposito, Precancerous lesions of the biliary tree Best Practice & Research in Clinical Gastroenterology. ,vol. 27, pp. 285- 297 ,(2013) , 10.1016/J.BPG.2013.04.002
Tania M. Welzel, Barry I. Graubard, Hashem B. El–Serag, Yasser H. Shaib, Ann W. Hsing, Jessica A. Davila, Katherine A. McGlynn, Risk Factors for Intrahepatic and Extrahepatic Cholangiocarcinoma in the United States: A Population-Based Case-Control Study Clinical Gastroenterology and Hepatology. ,vol. 5, pp. 1221- 1228 ,(2007) , 10.1016/J.CGH.2007.05.020
Yoshiaki Murakami, Kenichiro Uemura, Yasuo Hayashidani, Takeshi Sudo, Hiroki Ohge, Taijiro Sueda, Pancreatoduodenectomy for Distal Cholangiocarcinoma: Prognostic Impact of Lymph Node Metastasis World Journal of Surgery. ,vol. 31, pp. 337- 342 ,(2007) , 10.1007/S00268-006-0224-0