Intensive Care Unit Management of Patients with Severe Pulmonary Hypertension and Right Heart Failure

摘要: Despite advances in medical therapies, pulmonary arterial hypertension (PAH) continues to cause significant morbidity and mortality. Although the right ventricle (RV) can adapt an increase afterload, progression of vasculopathy that characterizes PAH causes many patients develop progressive ventricular failure. Furthermore, acute decompensation may from disorders lead either cardiac demand, such as sepsis, or including interruptions therapy, arrhythmia, embolism. The poor reserve ventricle, RV ischemia, adverse influence on left filling a global reduction oxygen delivery multiorgan There is paucity data guide clinicians caring for heart failure PAH. Treatment recommendations are frequently based animal models case series humans with other hypertension. Successful treatment often requires invasive hemodynamics be used monitor effect strategies primarily biological plausibility. Herein we have developed approach current understanding attempted paradigm physiological principles available evidence.