Chemical Carcinogenesis Models of Cancer: Back to the Future

摘要: Over a century has elapsed since the first demonstration that exposure to chemicals in coal tar can cause cancer animals. These observations provided an essential causal mechanistic link between environmental and increased risk of human populations. Mouse models chemical carcinogenesis have led concept multistage tumor development through distinct stages initiation, promotion, progression identified many genetic biological events involved these processes. Recent breakthroughs DNA sequencing now given us tools dissect complete genome architectures revealed chemically induced cancers mouse carry high point mutation load signatures reflect causative agent used for induction. Chemical may therefore provide route identify causes found further inform studies therapeutic drug resistance responses immu...