Polycyclic Aromatic Hydrocarbons Affect Functional Differentiation and Maturation of Human Monocyte-Derived Dendritic Cells
作者： Béatrice Laupeze , Laurence Amiot , Lydie Sparfel , Eric Le Ferrec , Renée Fauchet
DOI: 10.4049/JIMMUNOL.168.6.2652
关键词:
摘要: Polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (BP) are environmental carcinogens exhibiting potent immunosuppressive properties. To determine the cellular bases of this immunotoxicity, we have studied effects PAHs on differentiation, maturation, and function monocyte-derived dendritic cells (DC). Exposure to BP during monocyte differentiation into DC upon action GM-CSF IL-4 markedly inhibited up-regulation markers found in CD1a, CD80, CD40, without altering cell viability. Besides BP, dimethylbenz(a)anthracene benzanthracene also strongly altered CD1a levels. Moreover, generated presence displayed decreased endocytic activity. Features LPS-mediated maturation DC, CD83 IL-12 secretion, were impaired response treatment. BP-exposed poorly stimulated T proliferation mixed leukocyte reactions compared with their untreated counterparts. In contrast halogenated arylhydrocarbon 2,3,7,8-tetrachlorodibenzo-p-dioxin, which shares some features PAHs, including interaction receptor, failed phenotypically alter monocytes suggesting that binding receptor cannot mimic PAH DC. Overall, these data demonstrate exposure inhibits vitro functional blood Such an effect may contribute immunotoxicity contaminants due major role play APC development immune response.
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