Hypocretin (orexin) levels in cerebrospinal fluid of patients with narcolepsy: relationship to cataplexy and HLA DQB1*0602 status.
作者： Lois E. Krahn , V. Shane Pankratz , Lawrence Oliver , Bradley F. Boeve , Michael H. Silber
关键词:
摘要: Study Objectives: Hypocretin (orexin) deficiency (< 40 pg/ml) is highly associated with narcolepsy cataplexy (89.5%) and more specifically patients who are HLA DQB1*0602 positive (95.7%). The relationship between hypocretin-1 levels without or the allele less clear. MethodslDesign: This study compared cerebrospinal (CSF) in 13 to 4 negative cataplexy, 3 6 plus 15 neurologic controls. Setting: Data were collected at a sleep disorders center. PatientslParticipants: Twenty-six narcolepsy, as well Interventions: N/A Measurement & Results: Using analysis of variance techniques, statistically significant differences found CSF all other groups (P<0.01). Although sample size was small, subjects had lower than did (other group). Hypocretin-1 not age diagnosis, lumbar puncture, body mass index time puncture. Conclusion: data confirms previous finding that undetectable specific for cataplexy. suggests pathophysiology and, by extension, etiology this disorder distinctly different from conditions studied. reduced needs further study.
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