Alterations of the Cerebrospinal Fluid in Chronic Inflammatory Diseases of the Peripheral Nervous System

摘要: Chronic inflammatory neuropathies comprise a heterogeneous group of diseases mainly characterized by demyelinating pathology. The most common disease, CIDP (chronic polyneuropathy), can be further categorized based on the clinical symptoms and associated diseases. Three other syndromes have been well defined. Similar to CIDP, distal acquired sensory polyneuropathy (DADS) evolves with symmetrical symptoms. In contrast, multifocal motor neuropathy (MMN) (MADSAM, Lewis-Sumner syndrome) are asymmetric polyneuropathies. this chapter, we discuss CSF alterations in these four main chronic neuropathies, M proteins, vasculitic neuropathies. Although touch some hematological malignancies paraproteinemic polyneuropathies, paraneoplastic neurological PNS described separate chapter. Altogether, increased protein is supportive factor especially when electrophysiological criteria not definite. A number specific markers also investigated patients but their role differentiating different syndromes, supporting diagnosis MMN, or predicting course treatment responses inconclusive.