Expression of oligodendrocyte progenitor cell antigens by gliomas: Implications for the histogenesis of brain tumors

摘要: The early events in neoplastic transformation can be understood only by comparison of the cell with its nontransformed counterpart. most common central nervous system gliomas traditionally are thought to arise from mature astrocytes and oligodendrocytes. We examined possibility that a population glia has properties oligodendrocyte progenitors. These glial cells express NG2 chondroitin sulfate proteoglycan α receptor platelet-derived growth factor vivo. identified expression tissue seven oligodendrogliomas, three pilocytic astrocytomas, one five glioblastoma multiforme. data provide evidence tumors progenitor cells. Molecules expressed these should considered as targets for novel therapeutics.