Switching between P2Y12 inhibitors: Rationale, methods, and expected consequences.
作者： Piera Capranzano , Davide Capodanno
DOI: 10.1016/J.VPH.2019.03.001
关键词:
摘要: The pharmacological and clinical differences of the three recommended oral P2Y12 inhibitors (clopidogrel, prasugrel, ticagrelor) enable physicians to switch from one agent another that it is considered more appropriate in specific setting. Moreover, recent availability cangrelor, only intravenous inhibitor with a rapid onset offset its antiplatelet action, makes necessary this an for continued platelet inhibition after percutaneous coronary intervention. Several pharmacodynamic studies have provided information on how change drug, terms timing dosage, without running risk temporary impairment inhibition. In addition, several assessed impact switching between outcomes. Overall, these evidences prompted development extensive expert consensus document, set basis practice guidelines recommendations, stimulated systematic overviews. present article provides brief schematic summary topic inhibitors, focusing main practical issues: why therapies what are consequences such strategy.
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