Optimal Control of a Hybridoma Biore-actor. Changes Induced by Considering by-Products in the Objective Function
作者： Irina Dana Ofiţeru , Alexandru Woinaroschy , Vasile Lavric
DOI: 10.1016/S1570-7946(07)80159-3
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摘要: Abstract The main target in the production of monoclonal antibodies (MAbs) is reduction operating costs. One pertinent challenges improving yield MAbs through secondary metabolic products. Therefore searching for an optimal nutrients supplying strategy becomes mandatory. This study about influence by-products together with dead cell concentration upon performance a bioreactor production. byproducts and are considered objective function control system. Three cases were studied: fed batch, continuous sequence batch - continuous. optimization procedure was based genetic algorithms, which applied either glutamine set point computation mode, or determination time inlet flow profile both guaranteeing optimum antibody
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