GABAA Receptor Agonists, Partial Agonists, and Antagonists

摘要: The neutral amino acid, γ-aminobutyric acid (GABA), is an inhibitory transmitter in the central nervous system (CNS). Furthermore, GABA involved as a neurotransmitter and/or paracrine effector regulation of variety physiological mechanisms periphery. Some these latter functions may be under control; others are managed by local neurons. A large percentage, perhaps majority, neurons control. complex underlying GABA-mediated neurotransmission have been extensively studied, using broad spectrum electrophysiological, neurochemical, pharmacological, and recent years, molecular biological techniques (Krnjevic, 1974; Curtis Johnston, Olsen Venter, 1986; Redburn Schousboe, 1987; Bowery Nistico, 1989; et al., 1990; Biggio Costa, Schousboe 1992a).