Design of metal organic framework-enzyme based bioelectrodes as a novel and highly sensitive biosensing platform.

摘要: Nanocomposites combining the mesoporous iron(III) trimesate MIL-100(Fe) (MIL: Materiaux Institut Lavoisier) and platinum nanoparticles (Pt-NPs) have been used as immobilization matrices of glucose oxidase (GOx). Due to physico-chemical properties Pt-NPs (electroactivity) (high specific surface area pore volume, biocompatibility), resulting GOx–MIL-100(Fe)–PtNP bioelectrode exhibits excellent electrocatalytic performances for detection. This novel biosensor presents a high sensitivity 71 mA M−1 cm−2 under optimum conditions low limit detection 5 μM with response time (<5 s). In contrast, substitution iron by chromium or aluminum in MIL-100 leads much lower higher values, suggesting that centres may be involved synergistic effect which indeed enhances catalytic oxidation activity. Thus, this work extends scope MOF engineered cores field highly sensitive, durable biosensors.