Evidence for a direct action of amphetamine on dopamine metabolism in the rat substantia Nigra in vivo
作者： A. Argiolas , F. Fadda , E. Stefanini , G. L. Gessa
DOI: 10.1007/BF00507033
关键词:
摘要: The intraperitoneal administration of d-amphetamine (0.2–2.5 mg/kg) decreases dihydroxyphenylacetic acid (DOPAC) content not only in the caudate nucleus but also substantia nigra. This effect persists both nigra and after loss dopamine-sensitive adenylate cyclase presumably dopamine receptors, induced by intrastriatal injection kainic acid. These results indicate that amphetamine on DOPAC levels is mediated through a strionigral feedback loop.
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