Resuscitating adaptive Tregs with combination therapies

摘要: Induction of 'adaptive' regulatory T cells (Tregs) using islet-specific antigen vaccinations has been shown to prevent disease in various animal models for type 1 diabetes (T1D). Even though translation from bench bedside unsuccessful so far, this non-invasive approach is the Holy Grail safely achieve immune tolerance humans. We will discuss here fact that every response appears contain a balance adaptive effector and Treg cells. The evolution these population their specificities over time during development determine at which route given islet can be chosen augment such Tregs most efficiently. Their 'resuscitation' crucial long-term homeostasis micro-environment, ultimately needed cure T1D. Recent insight our studies shows short-term creation systemic milieu favours propagation, as it occurs after administration non Fc-binding anti-CD3, strongly enhance process. propose combination therapies with anti-CD3 or similar modulators lower vaccines induce step developing successful immune-based intervention