S-Fluorenylmethyl protection of the cysteine side chain upon Nα-Fmoc deprotection
作者： Johannes W Wehner , Thisbe K Lindhorst
DOI: 10.3762/BJOC.8.242
关键词:
摘要: Deprotection of an N(α)-Fmoc-protected glycocysteine derivative 7 with excess morpholine unexpectedly led to the fluorenylmethyl-protected thioether 8 in high yield. The suggested mechanism for this reaction comprises addition cysteine thiolate on exocyclic double bond dibenzofulvene, which is formed during Fmoc deprotection. influence base concentration transprotection was studied.
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