Cancer. A radical approach to treatment.
作者： John L. Cleveland , Michael B. Kastan
DOI: 10.1038/35030277
关键词:
摘要: A compound that kills leukaemia cells does so by inhibiting an enzyme keeps down the level of toxic reactive oxygen species. The result raises hope this compound, together with substances increase concentration these species, may be useful in treating some cancers.
nature.com
sci-hub.se 参考文章(8)
Kelvin JA Davies, None, Oxidative stress: the paradox of aerobic life Biochemical Society Symposia. ,vol. 61, pp. 1- 31 ,(1995) , 10.1042/BSS0610001
Sareh Parangi, Robert J. D'Amato, Nancy Klauber, Ernest Hamel, Evelyn Flynn, Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol. Cancer Research. ,vol. 57, pp. 81- 86 ,(1997)
Peng Huang, Li Feng, Elizabeth A. Oldham, Michael J. Keating, William Plunkett, Superoxide dismutase as a target for the selective killing of cancer cells Nature. ,vol. 407, pp. 390- 395 ,(2000) , 10.1038/35030140
Theodore Fotsis, Youming Zhang, Michael S. Pepper, Herman Adlercreutz, Roberto Montesano, Peter Paul Nawroth, Lothar Schweigerer, The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth Nature. ,vol. 368, pp. 237- 239 ,(1994) , 10.1038/368237A0
Mark Cushman, Hu-Ming He, John A. Katzenellenbogen, Chii M. Lin, Ernest Hamel, Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site. Journal of Medicinal Chemistry. ,vol. 38, pp. 2041- 2049 ,(1995) , 10.1021/JM00012A003
M. Sundaresan, Z.-X. Yu, V. J. Ferrans, K. Irani, T. Finkel, Requirement for Generation of H2O2 for Platelet-Derived Growth Factor Signal Transduction Science. ,vol. 270, pp. 296- 299 ,(1995) , 10.1126/SCIENCE.270.5234.296
T. Tsutsui, Y. Tamura, M. Hagiwara, T. Miyachi, H. Hikiba, C. Kubo, J.C. Barrett, Induction of mammalian cell transformation and genotoxicity by 2-methoxyestradiol, an endogenous metabolite of estrogen. Carcinogenesis. ,vol. 21, pp. 735- 740 ,(2000) , 10.1093/CARCIN/21.4.735
Tapas Mukhopadhyay, Jack A Roth, Induction of apoptosis in human lung cancer cells after wild-type p53 activation by methoxyestradiol Oncogene. ,vol. 14, pp. 379- 384 ,(1997) , 10.1038/SJ.ONC.1200835