Identifying Links Between Genotype and Phenotype Using Marker Loci and Candidate Genes

作者: Keith A. Crandall

DOI: 10.1007/978-1-4615-9855-8_8

关键词:

摘要: The elucidation of the causal links between variation at genetic level and emergent phenotype has been heart theoretical empirical studies in quantitative population genetics since rediscovery Mendel’s work synthesis Mendelism, Darwinism, Biometry through (Provine, 1971). Wright (1980, 1982) summarized historical emergence four predominant interpretations to relationship genotype (Figure 1). first 1A) represents a one mapping phenotype. This applies genes major effect, traditional Mendelian view inheritance (Haldane, 1932). Kimura’s (1983) neutral theory evolution is depicted 1C), where no seen phenotypic level. Figures 1B 1D represent views relationships Relationship (1B) multiple with minor additive effects on variation, forcefully put forth by Fisher (1930). (1D) genic pleiotropic producing maze interaction influencing (Wright, 1931; Wright, chapter outlines uses molecular techniques identify loci, genes, alleles, mutations associated

参考文章(98)
C F Sing, J Davignon, Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation. American Journal of Human Genetics. ,vol. 37, pp. 268- 285 ,(1985)
Craig L. Hanis, Charles F. Sing, Genetics of cellular, individual, family, and population variability Oxford University Press. ,(1993)
Robert W. Scotland, Darrell J. Siebert, D. M. Williams, Models in phylogeny reconstruction Published for the Systematics Association by Clarendon Press , Oxford University Press. ,(1994)
John B. S. Haldane, The Causes of Evolution ,(1966)
S Melia-Hancock, J M Gardiner, E H Coe, S Chao, D A Hoisington, Development of a core RFLP map in maize using an immortalized F2 population. Genetics. ,vol. 134, pp. 917- 930 ,(1993) , 10.1093/GENETICS/134.3.917
Zhao-Bang Zeng, Changjian Jiang, Multiple Trait Analysis of Genetic Mapping for Quantitative Trait Loci Genetics. ,vol. 140, pp. 1111- 1127 ,(1995) , 10.1093/GENETICS/140.3.1111