Whole Cell Vaccines—Past Progress and Future Strategies

摘要: Cancer vaccines have shown success in curing tumors preclinical models. Accumulating evidence also supports their ability to induce immune responses patients. In many cases, these correlate with improved clinical outcomes. However, cancer not yet demonstrated true potential trials. This is likely due the difficulty mounting a significant anti-tumor response patients advanced disease because of pre-existing tolerance mechanisms that are actively turning off recognition review will examine recent progress being made design and implementation whole cell vaccines, one vaccine approach simultaneously targets multiple tumor antigens activate response. These been antigen-specific T-cell responses. Preclinical studies evaluating given sequence other agents treatment modalities support use immunomodulating doses chemotherapy radiation, as well immune-modulating pathway–targeted monoclonal antibodies, enhance efficacy vaccines. Based on emerging data, trials currently exploring combinatorial immune-based therapies for cancer.