Shorter Telomere Length in Europeans than in Africans due to Polygenetic Adaptation.
作者： Matthew E.B. Hansen , Steven C. Hunt , Rivka C. Stone , Kent Horvath , Utz Herbig
DOI: 10.1093/HMG/DDW070
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摘要: Leukocyte telomere length (LTL), which reflects in other somatic tissues, is a complex genetic trait. Eleven SNPs have been shown genome-wide association studies to be associated with LTL at level of significance within cohorts European ancestry. It has observed that longer African Americans than Europeans. The underlying reason for this difference unknown. Here we show significantly sub-Saharan Africans both Europeans and Americans. Based on the 11 LTL-associated alleles data phase 3 1000 Genomes Project, shifts allele frequency Europe between Africa do not fit pattern expected by neutral drift. Our findings suggest differences influenced polygenic adaptation might explain, part, ethnic risks human diseases linked LTL.
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