Inhibitory effect of deltorphin-II on development of malaria in Plasmodium berghei-infected mice

摘要: Background. Drug resistance has been one of the main obstacles in fight against vector-borne infectious diseases. Among these diseases, malaria represents a serious public health challenge, mainly tropics, where vector-favourable climates are crucial factor. Each various anti-malarial drugs currently used this disease, such as quinolones, sulphonamides and artemisinins inadequate new strategies required. Peptides known to have huge number biological effects. Antimicrobial peptides (AMPs) proven be effective bacterial, fungal viral infections. This study explored effect peptide ‘deltorphin-II’ Plasmodium berghei-infected mice. Materials Methods. Mean percentage parasitaemia was calculated by studying infected erythrocytes after microscopic examination 10 from mice on days 4, 7, 10, 14 21 infection all groups. Results. Deltorphin-II shows maximum activity at dose 0.8 mg/kg/day day 4 21. Pre-treatment with naltriben abrogates deltorphin-II-mediated effect. Conclusion. inhibits development malaria, most probably via activation δ2 receptor.