Controlled oxygen administration in acute respiratory failure in chronic obstructive pulmonary disease

摘要: Abstract Controlled oxygen therapy may aggravate carbon dioxide retention during acute exacerbations of chronic obstructive pulmonary disease (COPD). Of 50 consecutive patients with COPD and respiratory failure, 13 required intubation because narcosis. With discriminant analysis their arterial tension (PaO 2 ) pH on admission, a diagram separated into those at high risk low for This was then used to predict narcosis in 73 failure who were treated controlled oxygen. In 16 these developed. Thirteen (81 per cent) predicted by the be this complication. Only two (4 judged mechanical ventilation. Utilizing an (PO ), (PCO patient's ventilatory response compared that ambulatory COPD. These data suggest hypoxemia acidosis are more discriminatory "carbon narcosis" than hypercapnia.