The mechanism of inactivation of penicillin by cysteine and other mercaptoamines.

摘要: Abstract The kinetics of penicillin inactivation by various mercaptoamines have been followed polarimetry. In the case primary mereaptoamines reactions are second order with respect to time and concentration reactants. By determining appropriate rate constants under different conditions pH ionic strength conclusion is reached that limiting step a bimolecular reaction involving mercaptide ion. mechanism probably involves formation semimercaptol. Several possible mechanisms for role amino group in opening β-lactam ring discussed. tertiary mercaptoamine N:N-dimethylcysteamine nearly follows first gives as end product partially racemized penicilloic acid.