Ameloblastic fibrosarcoma of the jaws: A clinicopathologic and DNA analysis of five cases and review of the literature with discussion of its relationship to ameloblastic fibroma

摘要: Ameloblastic fibrosarcoma, the malignant counterpart of ameloblastic fibroma, is a rare odontogenic tumorcharacterized by benign epithelium and fibrous stroma. We have compared nuclear DNA content five fibrosarcomas three fibromas image analysis. The were diploid, whereas 1 5 was aneuploid. There no correlation with histologic grade aneuploidy. These new cases also added to review literature, bringing total reported 51. fibrosarcoma occurs at later age (mean, 27.5 years) 14.6 22 years), which supports step-wise transformation. documentation that 44% developed in fibromas. In view this data cumulative recurrence rate 18.3% for it recommended be treated complete surgical excision long-term follow up rather than simple curettage or enucleation.