New 1,2,3‐triazole–(thio)barbituric acid hybrids as urease inhibitors: Design, synthesis, in vitro urease inhibition, docking study, and molecular dynamic simulation

作者: Mohammad S Asgari , Homa Azizian , Mohammad Nazari Montazer , Maryam Mohammadi‐Khanaposhtani , Mehdi Asadi

DOI: 10.1002/ARDP.202000023

关键词:

摘要: A new series of 1,2,3‐triazole–(thio)barbituric acid hybrids 8a–n was designed and synthesized on the basis of potent pharmacophores with urease inhibitory activity. Therefore, these …

参考文章(26)
S Eidt, M Stolte, R Fischer, Helicobacter pylori gastritis and primary gastric non-Hodgkin's lymphomas. Journal of Clinical Pathology. ,vol. 47, pp. 436- 439 ,(1994) , 10.1136/JCP.47.5.436
Mohsen Vosooghi, Soghra Farzipour, Mina Saeedi, Neda Babazadeh Shareh, Mohammad Mahdavi, Shabnam Mahernia, Alireza Foroumadi, Massoud Amanlou, Abbas Shafiee, Synthesis of novel 5-arylidene (thio)barbituric acid and evaluation of their urease inhibitory activity Journal of the Iranian Chemical Society. ,vol. 12, pp. 1487- 1491 ,(2015) , 10.1007/S13738-015-0617-9
Julius A. Vida, William R. Wilber, John F. Reinhard, Anticonvulsants. 2. Acyloxymethyl and halomethyl derivatives of barbituric acid and diphenylhydantoin. Journal of Medicinal Chemistry. ,vol. 14, pp. 187- ,(1971) , 10.1021/JM00285A003
F. Nabati, M. Habibi-Rezaei, M. Amanlou, A.A. Moosavi-Movahedi, Dioxane enhanced immobilization of urease on alkyl modified nano-porous silica using reversible denaturation approach Journal of Molecular Catalysis B: Enzymatic. ,vol. 70, pp. 17- 22 ,(2011) , 10.1016/J.MOLCATB.2011.01.014
Manuel R. Amieva, Emad M. El–Omar, Host-Bacterial Interactions in Helicobacter pylori Infection Gastroenterology. ,vol. 134, pp. 306- 323 ,(2008) , 10.1053/J.GASTRO.2007.11.009
H Rautelin, K Seppala, O V Renkonen, U Vainio, T U Kosunen, Role of metronidazole resistance in therapy of Helicobacter pylori infections. Antimicrobial Agents and Chemotherapy. ,vol. 36, pp. 163- 166 ,(1992) , 10.1128/AAC.36.1.163
Homa Azizian, Farzaneh Nabati, Amirhossein Sharifi, Farideh Siavoshi, Mohammad Mahdavi, Massoud Amanlou, Large-scale virtual screening for the identification of new Helicobacter pylori urease inhibitor scaffolds. Journal of Molecular Modeling. ,vol. 18, pp. 2917- 2927 ,(2012) , 10.1007/S00894-011-1310-2
Christopher A. Lipinski, Drug-like properties and the causes of poor solubility and poor permeability Journal of Pharmacological and Toxicological Methods. ,vol. 44, pp. 235- 249 ,(2000) , 10.1016/S1056-8719(00)00107-6
Daniel F. Veber, Stephen R. Johnson, Hung-Yuan Cheng, Brian R. Smith, Keith W. Ward, Kenneth D. Kopple, Molecular properties that influence the oral bioavailability of drug candidates. Journal of Medicinal Chemistry. ,vol. 45, pp. 2615- 2623 ,(2002) , 10.1021/JM020017N