Age at onset: the major determinant of outcome in Parkinson's disease.

摘要: Factors at presentation which influenced the course of disease and response to treatment were assessed in 125 de novo patients with Parkinson's disease. Ninety-eight available for re-assessment 5 years. Older presented earlier after onset symptoms, deteriorated more rapidly, significantly likely develop dementia impairment balance. Increasing age symmetrical predicted new appearance imbalance. Age did not predict dyskinesia or end dose failure. A low tremor score baseline female gender predictive early dyskinesia. Patients who experienced failure taking a higher levodopa. Once duration corrected for, no features The levodopa years was positively correlated severity as measured by Columbia score. We conclude that symptoms is major determinant treatment.