Combination Treatment With Meropenem Plus Levofloxacin Is Synergistic Against Pseudomonas aeruginosa Infection in a Murine Model of Pneumonia

摘要: Background. Meropenem plus levofloxacin treatment was shown to be a promising combination in our vitro hollow fiber infection model. We strove validate this finding murine Pseudomonas pneumonia model. Methods. A dose-ranging study with meropenem and alone against aeruginosa performed granulocytopenic Meropenem were administered partially humanize their pharmacokinetic profiles mouse serum. Total resistant bacterial populations estimated after 24 hours of therapy. Pharmacokinetic profiling both drugs plasma epithelial lining fluid, using population model. Results. Meropenem penetrations into fluid 39.3% 64.3%, respectively. Both monotherapies demonstrated good exposure responses. An innovative combination-therapy analytic approach that the statistically significantly synergistic (α = 2.475), as Bacterial seen control arm. Levofloxacin monotherapy selected for resistance itself. No subpopulations observed any therapy arm. Conclusions. The synergistic, producing kill suppression. Given track record safety each agent, may worthy clinical trial.