Decreased incidence of papillomas in mice with impaired EGFR function during multi‐stage skin carcinogenesis

摘要: Genetically modified mouse lines revealed that the epidermal growth factor receptor (EGFR) is essential for development and homoeostasis of epidermis hair follicles. However, more detailed studies have been precluded by shortened lifespan Egfr knockout mice. We employed line Wa5 (carrying a point mutation resulting in expression dominant negative receptor) to analyse impact significantly reduced EGFR signalling during multi-stage chemical skin carcinogenesis. Seven-week-old females control littermates received single application 7,12-dimethylbenz(a)anthracene followed multiple applications 12-O-tetradecanoylphorbol-13-acetate 26 weeks. mice remained free papillomas longer time developed fewer tumors than littermates. In contrast, mean tumor size was not different between groups. The present data indicate contributes carcinogenesis possibly acting as survival cells.