Late Inflammatory Reactions Induced by IgE Antibodies

摘要: Contrary to popular belief, IgE-mediated inflammatory reactions can last not just a matter of minutes, but for many hours. The concept biphasic responses induced by IgE antibodies has thus arisen. initial phase is the typical immediate hypersensitivity reaction, classically represented in skin wheal and flare response (WFR). This develops rapidly after injection antigen, peaks 10–20 min, then subsides within 1–2 hr. second designated as “late” reaction distinguish it from “delayed” or cell-mediated reaction. It represents continuation of, greater intensity than, phase. Typically, WFR begins fade 2 hr, 3–4 hr site undergoes renewed inflammation which reaches its greatest at 8–12 thereafter gradually resolves over 24–48 characteristics this late-phase (LPR) are quite different well-circumscribed, pruritic lesion characterized diffuse erythema, warmth, edema, tenderness, usually more extensive area resulting much discomfort than WFR.