Discovery of nonpeptide, peptidomimetic peptidase inhibitors that target alternate enzyme active site conformations.

摘要: Structure-generating programs provide rational methods to rapidly design novel scaffolds targeting the biologic receptor of choice. Recent research has demonstrated proteins equilibrate between families conformations (ensembles) for which drug may target. New are currently being developed utilizing structure-generating target alternate enzyme in an attempt overcome challenge developing therapeutically useful molecules. These new potential bioavailability problems encountered with peptide and peptide-like molecules by identifying small molecule scaffolds.