Recent Insights into Cell Surface Heparan Sulphate Proteoglycans and Cancer.

摘要: A small group of cell surface receptors are proteoglycans, possessing a core protein with one or more covalently attached glycosaminoglycan chains. They virtually ubiquitous and their chains major sites at which ligands many types interact. These proteoglycans can signal regulate important processes, such as adhesion, migration, proliferation, differentiation. Since ligands, growth factors, morphogens, cytokines, also implicated in tumour progression, it is increasingly apparent that impact behaviour. Here, we review some recent advances, emphasising tumour-related functions revealed only after modification processes subsequent to synthesis export the surface. include enzymes modify heparan sulphate structure, recycling whole fragmented into exosomes be paracrine effectors biomarkers, lateral interactions between calcium channels actin cytoskeleton.