Degeneration of vascular muscle cells in cerebral amyloid angiopathy of Alzheimer disease

摘要: In cerebral amyloid angiopathy, the amyloid-beta (A beta) deposits lie primarily in tunica media suggesting that smooth muscle cells play an important role A beta deposition. To define this role, we conducted immunocytochemical study of brain tissue from cases Alzheimer disease with extensive angiopathy and hemorrhage. Antibodies specific to recombinant protein precursor (beta PP) synthetic peptides homologous various PP sequences residue 18 689 PP695 were used. actin, tropomyosin, alpha-actinin or desmin used label cells. intensely recognized extracellular deposit. raised against other than domain PP-immunoreactivity was reduced regions deposits, since no by cytoskeletal markers observed ultrastructurally. order assess why is deposited media, biotin-labelled determine if can be locally retained. We found bound vessels but not elements. These findings suggest blood derives degenerating PP-containing