Linear peptide antibiotics

作者: Tucker Curran Roberts , Robert I. Higuchi , Peter Andrew Smith , Prasuna Paraselli , David Campbell

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摘要: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The provided can other overcome resistance conferred by single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases) and provide for a antibiotic Pharmaceutical compositions methods treatment using described also provided.

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