Vasculogenesis and angiogenesis in nonseminomatous testicular germ cell tumors.

摘要: Testicular germ cell tumors (TGCTs) comprise the vast majority of all testicular malignancies and are most common type cancer among young male adults. The nonseminomatous variant TGCTs is characterized by presence embryonic extraembryonic tissues together with a population pluripotent stem cells, so-called embryonal carcinoma. One main causes resistance these to therapy their ability invade adjacent metastasize into distant sites body. Both tumor processes highly favored neovascularization malignant tissue. New vessels can be generated means angiogenesis or vasculogenesis, both have been observed occur during vascularization. Nevertheless, precise contribution each process neoplastic vascular bed remains unknown. In addition, another known as tumor-derived in which cells give rise endothelial has also reported number types, including experimental TGCTs. participation cross talk 3 vascularization particular interest, given origin teratocarcinomas. Thus, present review, we discuss importance growth, invasion, metastasis teratocarcinomas summarize current state knowledge TGCT microenvironment its relationship Finally, therapeutic target for this malignancy.