Colorectal cancer atlas: An integrative resource for genomic and proteomic annotations from colorectal cancer cell lines and tissues
作者： David Chisanga , Shivakumar Keerthikumar , Mohashin Pathan , Dinuka Ariyaratne , Hina Kalra
DOI: 10.1093/NAR/GKV1097
关键词:
摘要: In order to advance our understanding of colorectal cancer (CRC) development and progression, biomedical researchers have generated large amounts OMICS data from CRC patient samples representative cell lines. However, these are deposited in various repositories or supplementary tables. A database which integrates heterogeneous resources enables analysis the multidimensional sets, specifically pertaining is currently lacking. Here, we developed Colorectal Cancer Atlas (http://www.colonatlas.org), an integrated web-based resource that catalogues genomic proteomic annotations identified tissues The catalogued to-date include sequence variations as well quantitative non-quantitative protein expression data. context signaling pathways, protein-protein interactions, Gene Ontology terms, domains post-translational modifications. Currently, contains for >13 711 tissues, >165 lines, 62 251 identifications, >8.3 million MS/MS spectra, >18 410 genes with (404 278 entries) 351 pathways variants. Overall, has been designed serve a central facilitate research CRC.
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