Mechanics of intact bone marrow

摘要: The current knowledge of bone marrow mechanics is limited to its viscous properties, neglecting the elastic contribution extracellular matrix. To get a more complete view marrow, we characterized intact yellow porcine using three different, but complementary techniques: rheology, indentation, and cavitation. Our analysis shows that elastic, has large amount intra- inter-sample heterogeneity, with an effective Young׳s modulus ranging from 0.25 24.7 kPa at physiological temperature. Each testing method was consistent across matched tissue samples, each provided unique benefits depending on user needs. We recommend bulk rheology capture effects temperature elasticity moduli, indentation for quantifying local cavitation mitigating destructive sample preparation. anticipate properties building in vitro models will elucidate mechanisms involved disease progression regenerative medicine.