Early life stress and metabolism

摘要: Exposure to stress is a normal and constant facet of life. However, excessive or chronic at particular phases brain development can have lasting detrimental effects on many aspects physiology, including appetite regulation metabolism. A specific window vulnerability the early life period, in utero immediately postnatally. At these times, psychological stress, such as parental withdrawal bereavement family, influence hypothalamic–pituitary–adrenal (HPA) axis development, resulting glucocorticoid production throughout Although additional mechanisms contribute aberrant programming feeding metabolism with HPA dysregulation play major role, excess glucocorticoids contributing chronically stimulated for palatable foods, well increased fat deposition. Here we will review recent work examining impact metabolic function animal models humans, examine some glucocorticoid-mediated by which this might occur, highlight those cases resilience face stress.