Early histopathologic changes predicting long-term kidney transplant survival.

摘要: IN THE CYCLOSPORINE era, short-term results of renal transplantation have dramatically improved; however, the rate graft loss in long-term has only marginally improved. Progressive and irreversible decline function suggests a continuous immunologic mechanism leading to chronic rejection (CR) or participation nonimmunologic events pathogenesis allograft deterioration. The risk factors predisposing CR are not completely known. Clinical variables including donor age, gender, HLA matching, immunosuppressive schedule, frequency intensity acute episodes been extensively investigated. Morphologic findings studied as most valuable indicators diagnosis dysfunction such nephrotoxicity. On other hand, authors showed high prevalence pathologic changes on biopsies taken from stable patients. Their value predicting outcome established. knowledge prognostic histologic lesions could facilitate therapeutic decisions thereby improve allograft. We explored relationship between for morphologic observed early well-functioning allografts. This study was done at single centre cohort transplant recipients with follow-up.