Role of biomarkers in early infectious complications after lung transplantation.

摘要: Background Infections and primary graft dysfunction are devastating complications in the immediate postoperative period following lung transplantation. Nowadays, reliable diagnostic tools not available. Biomarkers could improve early infection diagnosis. Methods Multicentre prospective observational study that included all centres authorized to perform transplantation Spain. Lung and/or presentation during (first week) was determined. were measured on ICU admission daily till discharge or for 6 consecutive days. Results We 233 patients. Median PCT levels significantly lower patients with no than Infection follow up days. similar PGD grades 1 2 increased grade 3. CRP groups, significant differences observed at any time point. In absence of 3, above median (0.50 ng/ml 1.17 day 1) associated more two- three-fold increase risk (adjusted Odds Ratio 2.37, 95% confidence interval 1.06 5.30 3.44, 1.52 7.78, respectively). Conclusions In severe dysfunction, procalcitonin can be useful detecting infections first week. 3 increases interferes capacity as a marker infection. superior diagnosis period.