Effects of chronic exposure to stressors on avoidance-escape behavior and on brain norepinephrine.

摘要: A single exposure to a severe stressor (either cold swim or inescapable shock) impairs subsequent performance in shuttle avoidance-escape task (1), deficit attributed reduction brain noradrenergic activity produced by these stressors. In the present paper, two experiments are described which examine how repeated such stressors affects (a) (Experiment 1), and (b) aspects of norepinephrine metabolism 2). Experiment 1 showed that, whereas subjects receiving shock large deficit, that received for 14 days performed similarly control group no stressor. 2 one session lower level hypothalamus cortex than did shock, neurochemical "habituation." Subjects elevated tyrosine hydroxylase depletion level, both caused decrease uptake 3H-norepinephrine slices vitro. Thus, it is concluded behavioral changes were observed after stressful conditions studied consistent with hypothesis responding following events due activity. Language: en