Anti-Cytokine Autoantibodies Preceding Onset of Autoimmune Polyendocrine Syndrome Type I Features in Early Childhood

摘要: Purpose Almost all patients with autoimmune polyendocrine syndrome (APS)-I have high titer neutralizing autoantibodies to type I interferons (IFN), especially IFN-ω and IFN-α2, whatever their clinical features onset-ages. About 90 % also antibodies interleukin (IL)-17A, IL-17F and/or IL-22; they correlate the chronic mucocutaneous candidiasis (CMC) that affects ~90 of patients. Our aim was explore how early manifestations endocrine cytokine appear in young APS-I That may hold clues very events autoimmunization process these