Investigation of Apoptosis-Involved Processes by Mass Spectrometric Identification of the Apoptosis-Associated Proteins in IgM-Induced Burkitt Lymphoma Cells

摘要: In recent years there has been an explosion of interest in various processes involved cell death, and new data have appeared. Although apoptosis, the programmed death plays a major role development, homeostasis immune response multicellular organisms controls lymphocyte growth selection, this research area not attracted great past for several reasons. First, efficient disposal apoptotic cells by phagocytosis is very rapid process. The amount small fraction total. Second, most often passive process entire organism, but play active roll death. Apoptotic can be distinguished from necrotic microscopic inspection. Necrotic pathologic form caused acute cellular injury resulting swelling loss membrane integrity. contrast, characterized controlled autodigestion functional, important proteins connected with shrinkage, blebbing chromatin condensation. nuclear DNA fragmented. integrity maintained, changes within give signal neighboring phagocytotic to feed on cells. without induction inflammatory response, although happens