Molecular and cell biology of the sarcoglycan complex

摘要: The original sarcoglycan (SG) complex has four subunits and comprises a subcomplex of the dystrophin-dystrophin-associated protein complex. Each SG gene been shown to be responsible for limb-girdle muscular dystrophy, called sarcoglycanopathy (SGP). In this review, we detail characteristics subunits, mechanism formation various molecules associated with We discuss molecular mechanisms SGP based on studies mostly using animal models. addition, describe other molecules, epsilon- zeta-SGs, special reference their expression roles in vascular smooth muscle, which are currently dispute. further consider maternally imprinted nature epsilon-SG gene. Finally, stress that cannot work by itself works larger system, transverse fixation forms an array dystrophies.