Studies on the metabolism and pharmacokinetics of tamoxifen in normal volunteers.

摘要: The densitometric analytic procedure used for tamoxifen can also be to quantify its desmethyl metabolite. In a study involving six healthy male volunteers, tablets were shown as bioavailable solution of citrate. After administration single dose 20 mg, peak serum levels 42 ng/ml; those the metabolite 12 ng/ml. half-lives drug and approximately 4 9 days, respectively, after dose. three widely separated doses, reversible increase in elimination half-life occurred.