The effects of intra-oral pain on motor cortex neuroplasticity associated with short-term novel tongue-protrusion training in humans.

摘要: Abstract To determine if short-term (15 min) training in a novel tongue-task is associated with rapid neuroplasticity of the tongue primary motor area (MI) human cerebral cortex, and intra-oral tonic pain affects MI performance. Nine healthy volunteers (7 men, 2 women, mean age 24 ± 1.1 years) participated two cross-over sessions which application to algesic chemical capsaicin (1%) or vehicle cream was randomized. Prior again immediately after 15 min tongue-protrusion task, transcranial magnetic stimulation (TMS) applied each session evoked potentials (MEPs) were recorded musculature first dorsal interosseous (FDI) muscle (as control). Neuroplasticity MI, as reflected significantly enhanced TMS–MEP stimulus–response curve reduced MEP threshold, observed but not session. Subjects’ overall performance scores higher than may rapidly occur association successful training, interferes these effects. These findings suggest that nociceptive input modulates impair ability learn new task.