Malignant Gliomas in Adults

作者: Patrick Y. Wen , Santosh Kesari

DOI: 10.1056/NEJMRA0708126

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摘要: Approximately 5% of patients with malignant gliomas have a family history gliomas. Some these familial cases are associated rare genetic syndromes, such as neurofibromatosis types 1 and 2, the Li−Fraumeni syndrome (germ-line p53 mutations an increased risk several cancers), Turcot’s (intestinal polyposis brain tumors). 10 However, most

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