Association of APOL1 Genotype with Renal Histology among Black HIV-Positive Patients Undergoing Kidney Biopsy
作者： Mohamed G. Atta , Michelle M. Estrella , Karl L. Skorecki , Jeffrey B. Kopp , Cheryl A. Winkler
DOI: 10.2215/CJN.07490715
关键词:
摘要: Background and objectives Prior studies have shown that the APOL1 risk alleles are associated with a greater of HIV-associated nephropathy FSGS among blacks who HIV positive. We sought to determine whether high–risk genotype incrementally improved prediction these underlying lesions beyond conventional clinical factors. Design, setting, participants, & measurements In cross-sectional study, we analyzed data from 203 positive, underwent kidney biopsies between 1996 2011, were genotyped for G1 G2 alleles. Predictive logistic regression models factors compared those also included using receiver-operating curves bootstrapping analyses crossvalidation. Results The addition HIV–related disease in predictive model non–HIV–associated FSGS, specifically, increasing c statistic 0.65 0.74 ( P =0.04). Although two significantly higher odds nephropathy, did not add this specific histopathology. Conclusions may provide additional diagnostic information traditional variables predicting spectrum contrast, although predicts it lacked high sufficient discrimination eliminate role biopsy care positive nephrotic proteinuria or unexplained disease.
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